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Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Benefits

  • Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Benefits
  • Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Benefits
  • Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Benefits
  • Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Benefits
  • Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Benefits
Brand Name︰GW0742
Country of Origin︰China
Unit Price︰CNY ¥ 10 / g
Minimum Order︰10 g
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Product Description


Product Name: GW0742
CAS:317318-84-6 
FW:C21H17F4NO3S2 
MW:471.4846 
Appearance:  White powder
Purity: 99.% min
Package: 10g/bag or as customers'request.
Test Method: HPLC

Benefit:The effects of a high-affinity PPAR-β/δ agonist, GW0742, in a mouse model of carrageenan (CAR)-induced pleurisy. Injection of CAR into the pleural cavity of mice elicited an acute inflammatory response characterized by accumulation of fluid containing a large number of neutrophils (polymorphonuclear leukocytes) in the pleural cavity, infiltration of polymorphonuclear leukocytes in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, TNF-α, and IL-1β. Furthermore, CAR induced lung apoptosis (Bax and Bcl-2 expression), and nitrotyrosine formation was determined by immunohistochemical analysis of lung tissues. Administration of GW0742 (0.3 mg/kg, i.p. bolus) 30 min before and 30 min after a challenge with CAR caused a reduction in all the parameters of inflammation measured. Thus, based on these findings, we propose that a PPAR-β/δ agonist such as GW0742 may be useful in the treatment of various inflammatory diseases.

Application:GW0742 is a potent and selective agonist for PPARδ, a member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. It has been shown to reduce atherosclerosis in LDLR-/- mice, to exert protective actions in an autoimmune model of demyelinating disease, and to induce differentiation and inhibit proliferation in keratinocytes.

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Wuhan Demeikai Biotechnology Co., Ltd is a company engaged in the research and development of chemical raw materials.Standardized production workshop, strict quality control system to ensure that each batch of goods are reached company's quality standards, to reach the quality requirements of customers; Experienced sales staff at your service, to solve all kinds of problems in the whole sales process for you;Professional delivery, to ensure the safety of international transportation, we do our best to ensure that customers can safely receive your goods.

Payment Terms︰Bitcoin,Moneygram and Wester Union
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